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Journal of Virology, November 2005, p. 14465-14469, Vol. 79, No. 22
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.22.14465-14469.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Herpes Simplex Virus Type 1 Locus That Encodes the Latency-Associated Transcript Enhances the Frequency of Encephalitis in Male BALB/c Mice

Clinton Jones,1* Melissa Inman,1 Weiping Peng,1 Gail Henderson,1 Alan Doster,1 Guey-Chuen Perng,2 and Anisa Kaenjak Angeletti3

Department of Veterinary and Biomedical Sciences, Nebraska Center for Virology, University of Nebraska, Fair Street at East Campus Loop, Lincoln, Nebraska 68583-0905,1 Department of Ophthalmology, College of Medicine, University of California at Irvine, UCIMC, Bldg. 55, Room 204, 101 The City Drive, Orange, California 92868-4380-02,2 School of Biological Sciences, Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska3

Received 26 May 2005/ Accepted 26 August 2005

Herpes simplex virus type 1 (HSV-1) is the leading cause of virus-induced encephalitis; however, the viral genes that regulate encephalitis have not been well characterized. In this study, we tested whether the LAT (latency-associated transcript) locus regulates the frequency of encephalitis in male or female mice. Male BALB/c mice are more susceptible to HSV-1-induced encephalitis than age-matched female BALB/c mice. Deletion of LAT coding sequences reduced the frequency of encephalitis. A recombinant virus containing the first 1.5 kb of the LAT coding sequence induces levels of encephalitis in male BALB/c mice similar to those induced by wild-type HSV-1.

* Corresponding author. Mailing address: Department of Veterinary and Biomedical Sciences, Nebraska Center for Virology, University of Nebraska, Fair Street at East Campus Loop, Rm. 104, Lincoln, NE 68583-0905. Phone: (402) 472-1890. Fax: (402) 472-9690. E-mail: cjones{at}unlnotes.unl.edu.

Journal of Virology, November 2005, p. 14465-14469, Vol. 79, No. 22
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.22.14465-14469.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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