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Journal of Virology, November 2005, p. 14088-14094, Vol. 79, No. 22
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.22.14088-14094.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Crystal Structure of Enteric Adenovirus Serotype 41 Short Fiber Head

Elena Seiradake and Stephen Cusack*

EMBL Grenoble Outstation, 38042 Grenoble Cedex 9, France

Received 12 July 2005/ Accepted 24 August 2005

Human enteric adenoviruses of species F contain two fibers in the same virion, a long fiber which binds to coxsackievirus and adenovirus receptor (CAR) and a short fiber of unknown function. We have determined the high-resolution crystal structure of the short fiber head of human adenovirus serotype 41 (Ad41). The short fiber head has the characteristic fold of other known fiber heads but has three unusual features. First, it has much shorter loops between the beta-strands. Second, one of the usually well-ordered beta-strands on the distal face of the fiber head is highly disordered and this same region is sensitive to digestion with pepsin, an enzyme occurring naturally in the intestinal tract, the physiological environment of Ad41. Third, the AB loop has a deletion giving it a distinct conformation incompatible with CAR binding.

* Corresponding author. Mailing address: EMBL Grenoble Outstation, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France. Phone: 33-4-76-20-72-38. Fax: 33-4-76-20-71-99. E-mail: cusack{at}embl-grenoble.fr.

Journal of Virology, November 2005, p. 14088-14094, Vol. 79, No. 22
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.22.14088-14094.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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