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Journal of Virology, January 2005, p. 1327-1332, Vol. 79, No. 2
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.2.1327-1332.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Three-Dimensional Localization of the Smallest Capsid Protein in the Human Cytomegalovirus Capsid

Xuekui Yu,1 Sanket Shah,1 Ivo Atanasov,1 Pierrette Lo,1 Fenyong Liu,2 William J. Britt,3,4 and Z. Hong Zhou1*

Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas,1 Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California,2 Department of Pediatrics,3 Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama4

Received 24 June 2004/ Accepted 23 August 2004

The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to major capsid protein subunits of the hexons, not the pentons. Thus, the SCPs of different herpesviruses illustrate that a protein can evolve significantly in sequence, structure, and function, while preserving its role in the architecture of the virus by binding to a specific partner in a specific oligomeric state.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin St., MSB 2.280, Houston, TX 77030. Phone: (713) 500-5358. Fax: (713) 500-0730. E-mail: z.h.zhou{at}uth.tmc.edu.

Journal of Virology, January 2005, p. 1327-1332, Vol. 79, No. 2
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.2.1327-1332.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Seo, J.-Y., Britt, W. J. (2008). Multimerization of Tegument Protein pp28 within the Assembly Compartment Is Required for Cytoplasmic Envelopment of Human Cytomegalovirus. J. Virol. 82: 6272-6287 [Abstract] [Full Text]  
  • Seo, J.-Y., Britt, W. J. (2006). Sequence Requirements for Localization of Human Cytomegalovirus Tegument Protein pp28 to the Virus Assembly Compartment and for Assembly of Infectious Virus.. J. Virol. 80: 5611-5626 [Abstract] [Full Text]  


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