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Journal of Virology, January 2005, p. 1125-1132, Vol. 79, No. 2
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.2.1125-1132.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Genomic Variation of the Fibropapilloma-Associated Marine Turtle Herpesvirus across Seven Geographic Areas and Three Host Species{dagger}

Rebecca J. Greenblatt,1,{ddagger} Sandra L. Quackenbush,2 Rufina N. Casey,1 Joel Rovnak,2 George H. Balazs,3 Thierry M. Work,4 James W. Casey,1* and Claudia A. Sutton1

Cornell University Department of Microbiology and Immunology, Ithaca, New York,1 Colorado State University Department of Microbiology, Immunology, and Pathology, Fort Collins, Colorado,2 National Marine Fisheries Service, Pacific Islands Fisheries Science Center, Honolulu Laboratory,3 United States Geological Survey, National Wildlife Health Center Honolulu Field Station, Honolulu, Hawaii4

Received 30 June 2004/ Accepted 30 August 2004

Fibropapillomatosis (FP) of marine turtles is an emerging neoplastic disease associated with infection by a novel turtle herpesvirus, fibropapilloma-associated turtle herpesvirus (FPTHV). This report presents 23 kb of the genome of an FPTHV infecting a Hawaiian green turtle (Chelonia mydas). By sequence homology, the open reading frames in this contig correspond to herpes simplex virus genes UL23 through UL36. The order, orientation, and homology of these putative genes indicate that FPTHV is a member of the Alphaherpesvirinae. The UL27-, UL30-, and UL34-homologous open reading frames from FPTHVs infecting nine FP-affected marine turtles from seven geographic areas and three turtle species (C. mydas, Caretta caretta, and Lepidochelys olivacea) were compared. A high degree of nucleotide sequence conservation was found among these virus variants. However, geographic variations were also found: the FPTHVs examined here form four groups, corresponding to the Atlantic Ocean, West pacific, mid-Pacific, and east Pacific. Our results indicate that FPTHV was established in marine turtle populations prior to the emergence of FP as it is currently known.

* Corresponding author. Mailing address: C5-142 Veterinary Medical Center, Cornell University, Ithaca, NY 13045. Phone: (607) 253-3412. Fax: (607) 253-3384. E-mail: jwc3{at}cornell.edu.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org/.

{ddagger} Present address: Department of Microbiology & Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210.

Journal of Virology, January 2005, p. 1125-1132, Vol. 79, No. 2
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.2.1125-1132.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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