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Journal of Virology, September 2005, p. 11537-11540, Vol. 79, No. 17
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.17.11537-11540.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Long-Term Presence of Virus-Specific Plasma Cells in Sensory Ganglia and Spinal Cord following Intravaginal Inoculation of Herpes Simplex Virus Type 2

Gregg N. Milligan,* Michael G. Meador, Chin-Fun Chu, Christal G. Young, Talitha L. Martin, and Nigel Bourne

Sealy Center for Vaccine Development, Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555-0436

Received 3 May 2005/ Accepted 15 June 2005

The tissue sites of long-term herpes simplex virus type 2 (HSV-2)-specific antibody production in mice and guinea pigs were identified. In addition to secondary lymphoid tissue and bone marrow, HSV-specific plasma cells were detected in spinal cords of mice up to 10 months after intravaginal inoculation with a thymidine kinase-deficient HSV-2 strain and in lumbosacral ganglia and spinal cords of guinea pigs inoculated with HSV-2 strain MS. The long-term retention of virus-specific plasma cells in the peripheral and central nervous systems following HSV infection may be important for resistance to reinfection of neuronal tissues or may play a role in modulation of reactivation from latency.

* Corresponding author. Mailing address: University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0436. Phone: (409) 747 8145. Fax: (409) 747-8150. E-mail: gnmillig{at}utmb.edu.

Journal of Virology, September 2005, p. 11537-11540, Vol. 79, No. 17
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.17.11537-11540.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Johnson, A. J., Chu, C.-F., Milligan, G. N. (2008). Effector CD4+ T-Cell Involvement in Clearance of Infectious Herpes Simplex Virus Type 1 from Sensory Ganglia and Spinal Cords. J. Virol. 82: 9678-9688 [Abstract] [Full Text]  


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