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Journal of Virology, August 2005, p. 10690-10700, Vol. 79, No. 16
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.16.10690-10700.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Complete Genome Sequence of J Virus Reveals a Unique Genome Structure in the Family Paramyxoviridae

Philippa J. M. Jack,1,2,{dagger} David B. Boyle,1 Bryan T. Eaton,1 and Lin-Fa Wang1*

CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220,1 The University of Melbourne, Department of Veterinary Science, Corner Park Drive and Flemington Road, Parkville, Victoria 3010, Australia2

Received 7 February 2005/ Accepted 3 May 2005

J virus (J-V) was isolated from feral mice (Mus musculus) trapped in Queensland, Australia, during the early 1970s. Although studies undertaken at the time revealed that J-V was a new paramyxovirus, it remained unclassified beyond the family level. The complete genome sequence of J-V has now been determined, revealing a genome structure unique within the family Paramyxoviridae. At 18,954 nucleotides (nt), the J-V genome is the largest paramyxovirus genome sequenced to date, containing eight genes in the order 3'-N-P/V/C-M-F-SH-TM-G-L-5'. The two genes located between the fusion (F) and attachment (G) protein genes, which have been named the small hydrophobic (SH) protein gene and the transmembrane (TM) protein gene, encode putative proteins of 69 and 258 amino acids, respectively. The 4,401-nt J-V G gene, much larger than other paramyxovirus attachment protein genes sequenced to date, encodes a putative attachment protein of 709 amino acids and distally contains a second open reading frame (ORF) of 2,115 nt, referred to as ORF-X. Taken together, these novel features represent the most significant divergence to date from the common six-gene genome structure of Paramyxovirinae. Although genome analysis has confirmed that J-V can be classified as a member of the subfamily Paramyxovirinae, it cannot be assigned to any of the five existing genera within this subfamily. Interestingly, a recently isolated paramyxovirus appears to be closely related to J-V, and preliminary phylogenetic analyses based on putative matrix protein sequences indicate that these two viruses will likely represent a new genus within the subfamily Paramyxovirinae.

* Corresponding author. Mailing address: CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia. Phone: 61-3-5227-5121. Fax: 61-3-5227-5555. E-mail: Linfa.wang{at}csiro.au.

{dagger} Philippa J. M. Jack's maiden surname was Miller.

Journal of Virology, August 2005, p. 10690-10700, Vol. 79, No. 16
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.16.10690-10700.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Jack, P. J. M., Anderson, D. E., Bossart, K. N., Marsh, G. A., Yu, M., Wang, L.-F. (2008). Expression of novel genes encoded by the paramyxovirus J virus. J. Gen. Virol. 89: 1434-1441 [Abstract] [Full Text]  


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