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Journal of Virology, August 2005, p. 10088-10092, Vol. 79, No. 15
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.15.10088-10092.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Identification of Two New HLA-A*1101-Restricted Tax Epitopes Recognized by Cytotoxic T Lymphocytes in an Adult T-Cell Leukemia Patient after Hematopoietic Stem Cell Transplantation

Nanae Harashima,1 Ryuji Tanosaki,2 Yukiko Shimizu,1 Kiyoshi Kurihara,1 Takao Masuda,1 Jun Okamura,3 and Mari Kannagi1*

Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, Tokyo 113-8519,1 Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo 104-0045,2 Clinical Research Division, National Kyusyu Cancer Center, Fukuoka 811-1395, Japan3

Received 26 January 2005/ Accepted 26 April 2005

We previously reported that Tax-specific CD8+ cytotoxic T lymphocytes (CTLs), directed to single epitopes restricted by HLA-A2 or A24, expanded in vitro and in vivo in peripheral blood mononuclear cells (PBMC) from some adult T-cell leukemia (ATL) patients after but not before allogeneic hematopoietic stem cell transplantation (HSCT). Here, we demonstrated similar Tax-specific CTL expansion in PBMC from another post-HSCT ATL patient without HLA-A2 or A24, whose CTLs equally recognized two newly identified epitopes, Tax88-96 and Tax272-280, restricted by HLA-A11, suggesting that these immunodominant Tax epitopes are present in the ATL patient in vivo.

* Corresponding author. Mailing address: Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Phone: 81-3-5803-5798. Fax: 81-3-5803-0235. E-mail: kann.impt{at}tmd.ac.jp.

Journal of Virology, August 2005, p. 10088-10092, Vol. 79, No. 15
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.15.10088-10092.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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