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Journal of Virology, June 2005, p. 7905-7910, Vol. 79, No. 12
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.12.7905-7910.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Investigation of the Multimerization Region of the Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Protein K-bZIP: the Proposed Leucine Zipper Region Encodes a Multimerization Domain with an Unusual Structure

Salama Al Mehairi, Eleanora Cerasoli, and Alison J. Sinclair*

School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom

Received 20 January 2005/ Accepted 3 March 2005

The K8 gene of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) shares many functional similarities with the BZLF1 gene of Epstein-Barr virus. The protein products of K8 and BZLF1, K-bZIP (RAP, K8) and Zta (BZLF1, ZEBRA, Z) have both been proposed to be members of the bZIP family of transcription factors, forming multimers via a coiled-coil motif termed a leucine zipper. Substantial evidence supporting this model for Zta is published. Here, we demonstrate that the proposed leucine zipper region of K-bZIP (amino acids 182 to 218) is required for multimer formation but that it does not fold as a coiled coil.

* Corresponding author. Mailing address: School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom. Phone: (44) 1273 678 194. Fax: (44) 1273 678 433. E-mail: a.j.sinclair{at}sussex.ac.uk.

Journal of Virology, June 2005, p. 7905-7910, Vol. 79, No. 12
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.12.7905-7910.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Schelcher, C., Al Mehairi, S., Verrall, E., Hope, Q., Flower, K., Bromley, B., Woolfson, D. N., West, M. J., Sinclair, A. J. (2007). Atypical bZIP Domain of Viral Transcription Factor Contributes to Stability of Dimer Formation and Transcriptional Function. J. Virol. 81: 7149-7155 [Abstract] [Full Text]  


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