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Journal of Virology, March 2004, p. 2454-2459, Vol. 78, No. 5
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.5.2454-2459.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Human CD4+ CD25+ Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

Einar M. Aandahl,1* Jakob Michaëlsson,1 Walter J. Moretto,1 Frederick M. Hecht,2 and Douglas F. Nixon1

Gladstone Institute of Virology and Immunology,1 Positive Health Program HIV Section at San Francisco General Hospital and Department of Medicine, University of California—San Francisco, San Francisco, California 941102

Received 17 August 2003/ Accepted 11 November 2003

Regulatory T (TR) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4+ CD25+ human TR cells suppress virus-specific T-cell responses. Depletion of TR cells from peripheral blood mononuclear cells enhances T-cell responses to cytomegalovirus and human immunodeficiency virus antigens. We propose that chronic viral infections lead to induction of suppressive TR cells that inhibit the antiviral immune response.

* Corresponding author. Present address: The Biotechnology Centre of Oslo, University of Oslo, P.O. Box 1125, Blindern, N-0317 Oslo, Norway. Phone: 47-22840521 or 47-92066046. Fax: 47-22840506. E-mail: aandahl{at}basalmed.uio.no.

Journal of Virology, March 2004, p. 2454-2459, Vol. 78, No. 5
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.5.2454-2459.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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