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Journal of Virology, November 2004, p. 12709-12711, Vol. 78, No. 22
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.22.12709-12711.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Seminal Fluid Enhances Replication of Human T-Cell Leukemia Virus Type 1: Implications for Sexual Transmission

Masako Moriuchi1 and Hiroyuki Moriuchi1,2*

Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences,1 Department of Pediatrics, Nagasaki University Hospital, Nagasaki, Japan2

Received 9 May 2004/ Accepted 12 July 2004

Seminal fluid enhanced human T-cell leukemia virus type 1 (HTLV-1) infection by transactivating the HTLV-1 long terminal repeat promoter, which is chromosomally integrated in a cell-type-dependent manner. Our data may indicate a potential role for seminal fluid in the sexual transmission of HTLV-1 and imply complex features of regulation of HTLV-1 expression.

* Corresponding author. Mailing address: Department of Pediatrics, Nagasaki University Hospital, Nagasaki 852-8501, Japan. Phone: 81-95-849-7297. Fax: 81-849-7301. E-mail: hiromori{at}net.nagasaki-u.ac.jp.

Journal of Virology, November 2004, p. 12709-12711, Vol. 78, No. 22
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.22.12709-12711.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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