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Journal of Virology, October 2004, p. 11401-11404, Vol. 78, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.20.11401-11404.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Macaque Model for Severe Acute Respiratory Syndrome

Thomas Rowe,1 Guangping Gao,2 Robert J. Hogan,1 Ronald G. Crystal,3 Thomas G. Voss,1 Rebecca L. Grant,2 Peter Bell,2 Gary P. Kobinger,2 Nelson A. Wivel,2 and James M. Wilson2*

Homeland Security and Emerging Infectious Disease Research Division, Southern Research Institute, Birmingham, Alabama,1 Gene Therapy Program, Division of Medical Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania,2 Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York3

Received 24 February 2004/ Accepted 21 May 2004

Rhesus and cynomolgus macaques were challenged with 107 PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.

* Corresponding author. Mailing address: 204 Wistar, 3601 Spruce St., Philadelphia, PA 19104. Phone: (215) 898-0819. Fax: (215) 898-6588. E-mail: wilsonjm{at}mail.med.upenn.edu.

Journal of Virology, October 2004, p. 11401-11404, Vol. 78, No. 20
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.20.11401-11404.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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