This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reyes-Sandoval, A.
Right arrow Articles by Ertl, H. C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reyes-Sandoval, A.
Right arrow Articles by Ertl, H. C. J.

 Previous Article  |  Next Article 

Journal of Virology, July 2004, p. 7392-7399, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7392-7399.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Human Immunodeficiency Virus Type 1-Specific Immune Responses in Primates upon Sequential Immunization with Adenoviral Vaccine Carriers of Human and Simian Serotypes

A. Reyes-Sandoval,1,2,{dagger} J. C. Fitzgerald,1,3,{dagger} R. Grant,3 S. Roy,3 Z. Q. Xiang,1 Y. Li,1 G. P. Gao,3 J. M. Wilson,3 and H. C. J. Ertl1*

Wistar Institute,1 Gene Therapy Program, Division of Medical Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104,3 Programa Institucional en Biomedicina Molecular, Instituto Politecnico Nacional, Mexico City, Mexico2

Received 17 December 2003/ Accepted 11 March 2004

Two triple immunization vaccine regimens with adenoviral vectors with E1 deleted expressing Gag of human immunodeficiency virus type 1 were tested for induction of T- and B-cell-mediated-immune responses in mice and in nonhuman primates. The vaccine carriers were derived from distinct serotypes of human and simian adenoviruses that fail to elicit cross-neutralizing antibodies expected to dampen the effect of booster immunizations. Both triple immunization regimens induced unprecedented frequencies of gamma interferon-producing CD8+ T cells to Gag in mice and monkeys that remained remarkably stable over time. In addition, monkeys developed Gag-specific interleukin-2-secreting T cells, presumably belonging to the CD4+ T-cell subset, and antibodies to both Gag and the adenoviral vaccine carriers.

* Corresponding author. Mailing address: Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104. Phone: (215) 898-3863. Fax: (215) 898-3953. E-mail: ertl{at}wistar.upenn.edu.

{dagger} These two authors contributed equally to the work.

Journal of Virology, July 2004, p. 7392-7399, Vol. 78, No. 14
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.14.7392-7399.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Haut, L. H., Ertl, H. C. J. (2009). Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine. J. Leukoc. Biol. 86: 779-793 [Abstract] [Full Text]  
  • Tatsis, N., Lasaro, M. O., Lin, S.-W., Xiang, Z. Q., Zhou, D., DiMenna, L., Li, H., Bian, A., Abdulla, S., Li, Y., Giles-Davis, W., Engram, J., Ratcliffe, S. J., Silvestri, G., Ertl, H. C., Betts, M. R. (2009). Adenovirus Vector-Induced Immune Responses in Nonhuman Primates: Responses to Prime Boost Regimens. J. Immunol. 182: 6587-6599 [Abstract] [Full Text]  
  • Liu, J., Ewald, B. A., Lynch, D. M., Denholtz, M., Abbink, P., Lemckert, A. A. C., Carville, A., Mansfield, K. G., Havenga, M. J., Goudsmit, J., Barouch, D. H. (2008). Magnitude and Phenotype of Cellular Immune Responses Elicited by Recombinant Adenovirus Vectors and Heterologous Prime-Boost Regimens in Rhesus Monkeys. J. Virol. 82: 4844-4852 [Abstract] [Full Text]  
  • Sridhar, S., Reyes-Sandoval, A., Draper, S. J., Moore, A. C., Gilbert, S. C., Gao, G. P., Wilson, J. M., Hill, A. V. S. (2008). Single-Dose Protection against Plasmodium berghei by a Simian Adenovirus Vector Using a Human Cytomegalovirus Promoter Containing Intron A. J. Virol. 82: 3822-3833 [Abstract] [Full Text]  
  • Worgall, S., Krause, A., Qiu, J., Joh, J., Hackett, N. R., Crystal, R. G. (2007). Protective Immunity to Pseudomonas aeruginosa Induced with a Capsid-Modified Adenovirus Expressing P. aeruginosa OprF. J. Virol. 81: 13801-13808 [Abstract] [Full Text]  
  • Tatsis, N., Fitzgerald, J. C., Reyes-Sandoval, A., Harris-McCoy, K. C., Hensley, S. E., Zhou, D., Lin, S.-W., Bian, A., Xiang, Z. Q., Iparraguirre, A., Lopez-Camacho, C., Wherry, E. J., Ertl, H. C. J. (2007). Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines. Blood 110: 1916-1923 [Abstract] [Full Text]  
  • McCoy, K., Tatsis, N., Korioth-Schmitz, B., Lasaro, M. O., Hensley, S. E., Lin, S.-W., Li, Y., Giles-Davis, W., Cun, A., Zhou, D., Xiang, Z., Letvin, N. L., Ertl, H. C. J. (2007). Effect of Preexisting Immunity to Adenovirus Human Serotype 5 Antigens on the Immune Responses of Nonhuman Primates to Vaccine Regimens Based on Human- or Chimpanzee-Derived Adenovirus Vectors. J. Virol. 81: 6594-6604 [Abstract] [Full Text]  
  • Thorner, A. R., Lemckert, A. A. C., Goudsmit, J., Lynch, D. M., Ewald, B. A., Denholtz, M., Havenga, M. J. E., Barouch, D. H. (2006). Immunogenicity of Heterologous Recombinant Adenovirus Prime-Boost Vaccine Regimens Is Enhanced by Circumventing Vector Cross-Reactivity. J. Virol. 80: 12009-12016 [Abstract] [Full Text]  
  • McConnell, M. J., Hanna, P. C., Imperiale, M. J. (2006). Cytokine Response and Survival of Mice Immunized with an Adenovirus Expressing Bacillus anthracis Protective Antigen Domain 4. Infect. Immun. 74: 1009-1015 [Abstract] [Full Text]  
  • Barratt-Boyes, S. M., Soloff, A. C., Gao, W., Nwanegbo, E., Liu, X., Rajakumar, P. A., Brown, K. N., Robbins, P. D., Murphey-Corb, M., Day, R. D., Gambotto, A. (2006). Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors. J. Gen. Virol. 87: 139-149 [Abstract] [Full Text]  
  • Hensley, S. E., Giles-Davis, W., McCoy, K. C., Weninger, W., Ertl, H. C. J. (2005). Dendritic Cell Maturation, but Not CD8+ T Cell Induction, Is Dependent on Type I IFN Signaling during Vaccination with Adenovirus Vectors. J. Immunol. 175: 6032-6041 [Abstract] [Full Text]  
  • Hashimoto, M., Boyer, J. L., Hackett, N. R., Wilson, J. M., Crystal, R. G. (2005). Induction of Protective Immunity to Anthrax Lethal Toxin with a Nonhuman Primate Adenovirus-Based Vaccine in the Presence of Preexisting Anti-Human Adenovirus Immunity. Infect. Immun. 73: 6885-6891 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»