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Journal of Virology, June 2004, p. 6688-6691, Vol. 78, No. 12
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.12.6688-6691.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Postattachment Events Associated with Viral Entry Are Necessary for Induction of Interferon-Stimulated Genes by Human Cytomegalovirus

James R. Netterwald,1 Thomas R. Jones,1 William J. Britt,2 Shao-Jun Yang,1 Ian P. McCrone,1 and Hua Zhu1*

Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103,1 Department of Pediatrics, Microbiology and Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 352332

Received 1 December 2003/ Accepted 18 February 2004

Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, 225 Warren St., Newark, NJ 07101-1709. Phone: (973) 972-4483. Fax: (973) 972-8981. E-mail: zhuhu{at}umdnj.edu.

Journal of Virology, June 2004, p. 6688-6691, Vol. 78, No. 12
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.12.6688-6691.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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