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Journal of Virology, May 2004, p. 5520-5522, Vol. 78, No. 10
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.10.5520-5522.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Effects of Antibody on Viral Kinetics in Simian/Human Immunodeficiency Virus Infection: Implications for Vaccination

Lei Zhang,1 Ruy M. Ribeiro,2,{dagger} John R. Mascola,3 Mark G. Lewis,4 Gabriela Stiegler,5 Hermann Katinger,5 Alan S. Perelson,2* and Miles P. Davenport1

Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales 2052, Australia,1 Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545,2 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,3 BIOQUAL, Inc., Rockville, Maryland 20850,4 Institute of Applied Microbiology, University of Agriculture, Vienna, Austria5

Received 9 November 2003/ Accepted 24 January 2004

Passive antibody treatment of macaques prior to simian/human immunodeficiency virus infection produces "sterilizing immunity" in some animals and long-term reductions in viral loads in others. Analysis of viral kinetics suggests that antibody mediates sterilizing immunity by its effects on the initial viral inoculum. By contrast, reduction in peak viral load later in infection prevents CD4 depletion and contributes to long-term viral control.

* Corresponding author. Mailing address: Theoretical Biology and Biophysics, MS-K710, Los Alamos National Laboratory, Los Alamos, NM 87545. Phone: (505) 667-6829. Fax: (505) 665-3493. E-mail: asp{at}lanl.gov.

{dagger} Present address: Department of Zoology, University of Oxford, Oxford, United Kingdom.

Journal of Virology, May 2004, p. 5520-5522, Vol. 78, No. 10
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.10.5520-5522.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Davenport, M. P., Zhang, L., Bagchi, A., Fridman, A., Fu, T.-M., Schleif, W., Shiver, J. W., Ribeiro, R. M., Perelson, A. S. (2005). High-Potency Human Immunodeficiency Virus Vaccination Leads to Delayed and Reduced CD8+ T-Cell Expansion but Improved Virus Control. J. Virol. 79: 10059-10062 [Abstract] [Full Text]  


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