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Journal of Virology, May 2004, p. 5486-5490, Vol. 78, No. 10
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.10.5486-5490.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Receptor-Dependent Coronavirus Infection of Dendritic Cells

Brian C. Turner,1 Erin M. Hemmila,1 Nicole Beauchemin,2 and Kathryn V. Holmes1*

Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80262,1 McGill Cancer Centre and Departments of Biochemistry, Medicine, and Oncology, McGill University, Montreal, Quebec, Canada2

Received 4 August 2003/ Accepted 9 February 2004

In several mammalian species, including humans, coronavirus infection can modulate the host immune response. We show a potential role of dendritic cells (DC) in murine coronavirus-induced immune modulation and pathogenesis by demonstrating that the JAW SII DC line and primary DC from BALB/c mice and p/p mice with reduced expression of the murine coronavirus receptor, murine CEACAM1a, are susceptible to murine coronavirus infection by a receptor-dependent pathway.

* Corresponding author. Mailing address: Department of Microbiology, Campus Box B-175, SOM Bldg., Room 4801, 4200 East 9th Ave., Denver, CO 80262. Phone: (303) 315-7220. Fax: (303) 315-6785. E-mail: kathryn.holmes{at}uchsc.edu.

Journal of Virology, May 2004, p. 5486-5490, Vol. 78, No. 10
0022-538X/04/$08.00+0     DOI: 10.1128/JVI.78.10.5486-5490.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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