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Journal of Virology, April 2003, p. 5037-5038, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.5037-5038.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

A Novel Antiviral Intervention Results in More Accurate Assessment of Human Immunodeficiency Virus Type 1 Replication Dynamics and T-Cell Decay In Vivo

Martin Markowitz,1* Michael Louie,1 Arlene Hurley,1 Eugene Sun,2 Michele Di Mascio,3 Alan S. Perelson,3 and David D. Ho1

Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York,1 Abbott Laboratories, Abbott Park, Illinois,2 Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico3

Received 10 October 2002/ Accepted 25 January 2003

Mathematical models provide an understanding of in vivo replication kinetics of human immunodeficiency virus type 1 (HIV-1). With a novel intervention designed for increased potency, we have more accurately deduced the half-lives of virus-producing CD4+ T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication.

* Corresponding author. Mailing address: Aaron Diamond AIDS Research Center, 455 First Ave., 7th floor, New York, NY 10016. Phone: (212) 448-5020. Fax: (212) 725-1126. E-mail: mmarkowitz{at}adarc.org.

Journal of Virology, April 2003, p. 5037-5038, Vol. 77, No. 8
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.8.5037-5038.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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