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Journal of Virology, April 2003, p. 4396-4400, Vol. 77, No. 7
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.7.4396-4400.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Role of CD8+ Lymphocytes in Control and Clearance of Measles Virus Infection of Rhesus Monkeys

Sallie R. Permar,1,2 Sherry A. Klumpp,3 Keith G. Mansfield,3 Woong-Ki Kim,1 Darci A. Gorgone,1 Michelle A. Lifton,1 Kenneth C. Williams,1 Jörn E. Schmitz,1 Keith A. Reimann,1 Michael K. Axthelm,4 Fernando P. Polack,2 Diane E. Griffin,2 and Norman L. Letvin1*

Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215,1 W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205,2 New England Regional Primate Center, Harvard Medical School, Southborough, Massachusetts 01772,3 Oregon Regional Primate Center, Oregon Health and Sciences University, Beavertown, Oregon 970064

Received 9 September 2002/ Accepted 27 December 2002

The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8+ cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8+ lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8+ lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8+ lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.

* Corresponding author. Mailing address: Division of Viral Pathogenesis, BIDMC, 330 Brookline Ave., RE-113, Boston, MA 02215. Phone: (617) 667-2766. Fax: (617) 667-8210. E-mail: nletvin{at}caregroup.harvard.edu.

Journal of Virology, April 2003, p. 4396-4400, Vol. 77, No. 7
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.7.4396-4400.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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