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Journal of Virology, March 2003, p. 3297-3300, Vol. 77, No. 5
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.5.3297-3300.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Mumps Virus Decreases Testosterone Production and Gamma Interferon-Induced Protein 10 Secretion by Human Leydig Cells

Ronan Le Goffic,1 Thomas Mouchel,1 Annick Ruffault,2 Jean-Jacques Patard,3 Bernard Jégou,1 and Michel Samson1*

INSERM U. 435/GERM, Université de Rennes I, Campus de Beaulieu, 35042 Rennes,1 Service de Bactériologie-Virologie,2 Service d'Urologie, CHU Ponchaillou, 35000 Rennes, France3

Received 10 June 2002/ Accepted 20 November 2002

Mumps virus is responsible for sterility. Here, we show that the mumps virus infects Leydig cells in vitro and totally inhibits testosterone secretion and that ribavirin in mumps virus-infected Leydig cell cultures completely restores testosterone production. Moreover, we show that gamma interferon-induced protein 10 (IP-10) is highly expressed by mumps virus-infected Leydig cells and that ribavirin does not block IP-10 production.

* Corresponding author. Mailing address: Université de Rennes I, GERM-INSERM U. 435, Campus de Beaulieu, 35042 Rennes cedex, Bretagne, France. Phone: 33-2-23 23 59 27. Fax: 33-2-23 23 50 55. E-mail: michel.samson{at}rennes.inserm.fr.

Journal of Virology, March 2003, p. 3297-3300, Vol. 77, No. 5
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.5.3297-3300.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Le Tortorec, A., Denis, H., Satie, A-P., Patard, J-J., Ruffault, A., Jegou, B., Dejucq-Rainsford, N. (2008). Antiviral responses of human Leydig cells to mumps virus infection or poly I:C stimulation. Hum Reprod 23: 2095-2103 [Abstract] [Full Text]  
  • Roulet, V., Satie, A.-P., Ruffault, A., Tortorec, A. L., Denis, H., Guist'hau, O., Patard, J.-J., Rioux-Leclerq, N., Gicquel, J., Jegou, B., Dejucq-Rainsford, N. (2006). Susceptibility of Human Testis to Human Immunodeficiency Virus-1 Infection in Situ and in Vitro. Am. J. Pathol. 169: 2094-2103 [Abstract] [Full Text]  


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