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Journal of Virology, February 2003, p. 2736-2740, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2736-2740.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Expression of the Major Histocompatibility Complex Class I Molecule Mamu-A*01 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

Bianca R. Mothé,1,2 Jason Weinfurter,1 Chenxi Wang,3 William Rehrauer,1 Nancy Wilson,1 Todd M. Allen,1 David B. Allison,3 and David I. Watkins1,2*

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715,1 Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53792,2 Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 352943

Received 18 July 2002/ Accepted 7 November 2002

Several HLA alleles are associated with attenuated human immunodeficiency virus disease progression. We explored the relationship between the expression of particular major histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency virus SIVmac239-infected macaques. Of the common MHC class I alleles, animals that expressed Mamu-A*01 exhibited the best control of viral replication.

* Corresponding author. Mailing address: Wisconsin Regional Primate Research Center, 1220 Capitol Ct., Madison, WI 53715-1299. Phone: (608) 265-3380. Fax: (608) 265-8084. E-mail: watkins{at}primate.wisc.edu.

Journal of Virology, February 2003, p. 2736-2740, Vol. 77, No. 4
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.4.2736-2740.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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