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Journal of Virology, February 2003, p. 2251-2257, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2251-2257.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Frequency and Phenotype of Circulating V{alpha}24/Vß11 Double-Positive Natural Killer T Cells during Hepatitis C Virus Infection

Michaela Lucas,1 Stephan Gadola,2 Ute Meier,3 Neil T. Young,4 Gillian Harcourt,1 Anastasios Karadimitris,2 Nikki Coumi,1 Dave Brown,5 Geoff Dusheiko,5 Vincenzo Cerundolo,2 and Paul Klenerman1*

Peter Medawar Building for Pathogen Research,1 Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine,2 University of Oxford, and Nuffield Department of Surgery, John Radcliffe Hospital, Oxford,4 The Edward Jenner Institute for Vaccine Research, Compton,3 Centre for Hepatology, Royal Free Hospital, London, United Kingdom5

Received 2 July 2002/ Accepted 26 October 2002

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, V{alpha}24/Vß11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike V{alpha}24/Vß11 NKT cells found in blood, those in the liver appeared to be recently activated.

* Corresponding author. Mailing address: Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Rd., Oxford OX1 3SY, United Kingdom. Phone: 44-1865-281885. Fax: 44-1865-281236. E-mail: klener{at}molbiol.ox.ac.uk.

Journal of Virology, February 2003, p. 2251-2257, Vol. 77, No. 3
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.3.2251-2257.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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