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Journal of Virology, December 2003, p. 13403-13406, Vol. 77, No. 24
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.24.13403-13406.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Characterization of Murine Leukemia Virus Restriction in Mammals

Caroline Besnier,1 Laura Ylinen,1 Benjamin Strange,1 Adrian Lister,2 Yasuhiro Takeuchi,1 Stephen P. Goff,3 and Greg J. Towers1,3*

Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF,1 Department of Biology, University College London, London WC1E 6BT, United Kingdom,2 Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 100323

Received 9 July 2003/ Accepted 5 September 2003

Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked.

* Corresponding author. Mailing address: Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, 46 Cleveland St., London W1T 4JF, United Kingdom. Phone: 44-20-7679-9535. Fax: 44-20-7679-9555. E-mail: g.towers{at}ucl.ac.uk.

Journal of Virology, December 2003, p. 13403-13406, Vol. 77, No. 24
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.24.13403-13406.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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