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Journal of Virology, November 2003, p. 12373-12377, Vol. 77, No. 22
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.22.12373-12377.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

A Bipartite Late-Budding Domain in Human Immunodeficiency Virus Type 1

Juan Martin-Serrano and Paul D. Bieniasz*

Aaron Diamond AIDS Research Center and the Rockefeller University, New York, New York

Received 9 May 2003/ Accepted 7 August 2003

Human immunodeficiency virus type 1 (HIV-1) encodes a PTAP motif within the p6 domain of Gag that recruits Tsg101 and associated factors to facilitate virion budding. In this study, we use trans-complementation assays to demonstrate that the PTAP motif acts synergistically with additional p6 sequences to mediate the formation of infectious extracellular HIV-1 virions. These studies suggest that Tsg101 recruitment is necessary but not sufficient to account for late-budding activity exhibited by HIV-1 p6.

* Corresponding author. Mailing address: Aaron Diamond AIDS Research Center, 455 First Ave., New York, NY 10021. Phone: (212) 448-5070. Fax: (212) 725-1126. E-mail: pbienias{at}adarc.org.

Journal of Virology, November 2003, p. 12373-12377, Vol. 77, No. 22
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.22.12373-12377.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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