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 Previous Article

Journal of Virology, November 2003, p. 11859-11866, Vol. 77, No. 21
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.21.11859-11866.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Induction of Protective Immunity against Malaria by Priming-Boosting Immunization with Recombinant Cold-Adapted Influenza and Modified Vaccinia Ankara Viruses Expressing a CD8+-T-Cell Epitope Derived from the Circumsporozoite Protein of Plasmodium yoelii

Gloria González-Aseguinolaza,1 Yurie Nakaya,2 Alberto Molano,1 Edward Dy,1 Mariano Esteban,3 Dolores Rodríguez,3 Juan Ramón Rodríguez,3,{dagger} Peter Palese,2 Adolfo García-Sastre,2* and Ruth S. Nussenzweig1

Department of Medical & Molecular Parasitology, NYU School of Medicine,1 Department of Microbiology, Mount Sinai School of Medicine, New York, New York,2 Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, CSIC, Madrid, Spain3

Received 13 June 2003/ Accepted 28 July 2003

We immunized mice with an attenuated (cold-adapted) influenza virus followed by an attenuated vaccinia virus (modified vaccinia virus Ankara), both expressing a CD8+-T-cell epitope derived from malaria sporozoites. This vaccination regimen elicited high levels of protection against malaria. This is the first time that the vaccine efficacy of a recombinant cold-adapted influenza virus vector expressing a foreign antigen has been evaluated.

* Corresponding author. Mailing address: Department of Microbiology, Box 1124, Mount Sinai School of Medicine, 1 Gustave L. Levy Pl., New York, NY 10029. Phone: (212) 241-7769. Fax: (212) 534-1684. E-mail: adolfo.garcia-sastre{at}mssm.edu.

{dagger} Present address: Bionostra, Tres Cantos, 28760 Madrid, Spain.

Journal of Virology, November 2003, p. 11859-11866, Vol. 77, No. 21
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.21.11859-11866.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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