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Journal of Virology, November 2003, p. 11798-11808, Vol. 77, No. 21
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.21.11798-11808.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Astrovirus Induces Diarrhea in the Absence of Inflammation and Cell Death

Matthew D. Koci,1,2 Lindsey A. Moser,2 Laura A. Kelley,3 Diane Larsen,4 Corrie C. Brown,1 and Stacey Schultz-Cherry2*

Department of Pathology, University of Georgia, Athens, Georgia 30602,1 Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 53706,2 Southeast Poultry Research Laboratory, USDA Agricultural Research Station, Athens, Georgia 30605,3 Merial Limited, Duluth, Georgia 30096-46404

Received 18 March 2003/ Accepted 17 July 2003

Astroviruses are a leading cause of infantile viral gastroenteritis worldwide. Very little is known about the mechanisms of astrovirus-induced diarrhea. One reason for this is the lack of a small-animal model. Recently, we isolated a novel strain of astrovirus (TAstV-2) from turkeys with the emerging infectious disease poult enteritis mortality syndrome. In the present studies, we demonstrate that TAstV-2 causes growth depression, decreased thymus size, and enteric infection in infected turkeys. Infectious TAstV-2 can be recovered from multiple tissues, including the blood, suggesting that there is a viremic stage during infection. In spite of the severe diarrhea, histopathologic changes in the intestine were mild and there was a surprising lack of inflammation. This may be due to the increased activation of the potent immunosuppressive cytokine transforming growth factor beta during astrovirus infection. These studies suggest that the turkey will be a useful small-animal model with which to study astrovirus pathogenesis and immunity.

* Corresponding author. Present address: Department of Medical Microbiology and Immunology, 1300 University Ave., Room 417 SMI, Madison, WI 53706. Phone: (608) 265-6462. Fax: (608) 262-8418. E-mail: slschul2{at}wisc.edu.

Journal of Virology, November 2003, p. 11798-11808, Vol. 77, No. 21
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.21.11798-11808.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jindal, N., Patnayak, D. P., Ziegler, A. F., Lago, A., Goyal, S. M. (2009). Experimental reproduction of poult enteritis syndrome: Clinical findings, growth response, and microbiology. Poult. Sci. 88: 949-958 [Abstract] [Full Text]  
  • Moser, L. A., Schultz-Cherry, S. (2008). Suppression of Astrovirus Replication by an ERK1/2 Inhibitor. J. Virol. 82: 7475-7482 [Abstract] [Full Text]  
  • Bonaparte, R. S., Hair, P. S., Banthia, D., Marshall, D. M., Cunnion, K. M., Krishna, N. K. (2008). Human Astrovirus Coat Protein Inhibits Serum Complement Activation via C1, the First Component of the Classical Pathway. J. Virol. 82: 817-827 [Abstract] [Full Text]  
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