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Journal of Virology, October 2003, p. 10780-10789, Vol. 77, No. 20
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.20.10780-10789.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Oral Vaccination of Mice with Adenoviral Vectors Is Not Impaired by Preexisting Immunity to the Vaccine Carrier

Z. Q. Xiang,1 G. P. Gao,2 A. Reyes-Sandoval,1 Y. Li,1 J. M. Wilson,2 and H. C. J. Ertl1*

The Wistar Institute,1 Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania2

Received 7 May 2003/ Accepted 14 July 2003

E1 deletion adenoviral vectors of the human serotype 5 (AdHu5) and the chimpanzee serotype 68 (AdC68) expressing the rabies virus glycoprotein (rab.gp) were tested for induction of transgene product-specific antibodies upon intranasal or oral immunization of newborn mice. Both vectors induced antibodies to rabies virus that could be detected in serum and mucosal secretions. Serum rabies virus-neutralizing antibody titers sufficed to protect neonatally vaccinated mice against a subsequent challenge with rabies virus. The efficacy of the AdHu5rab.gp vector given orally to newborn mice born to AdHu5-immune dams was not impaired by maternally transferred antibodies to the vaccine carrier.

* Corresponding author. Mailing address: The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104. Phone: (215) 898-3863. Fax: (215) 898-3953. E-mail: ertl{at}wistar.upenn.edu.

Journal of Virology, October 2003, p. 10780-10789, Vol. 77, No. 20
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.20.10780-10789.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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