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Journal of Virology, September 2003, p. 9716-9722, Vol. 77, No. 17
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.17.9716-9722.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4+ T Cells in Patients with HTLV-1-Associated Neurological Disease

Peter K. C. Goon,1 Tadahiko Igakura,1,{dagger} Emmanuel Hanon,1 Angelina J. Mosley,1 Becca Asquith,1 Keith G. Gould,1 Graham P. Taylor,2,{ddagger} Jonathan N. Weber,2 and Charles R. M. Bangham1*

Department of Immunology,1 Genito-Urinary Medicine and Communicable Diseases, Imperial College London, London W2 1PG, United Kingdom2

Received 31 March 2003/ Accepted 4 June 2003

Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4+ T cells play a role in the pathogenesis of HAM/TSP.

* Corresponding author. Mailing address: Department of Immunology, Imperial College London, St. Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom. Phone: 44 20 75943730. Fax: 44 20 74020653. E-mail: c.bangham{at}imperial.ac.uk.

{dagger} Present address: Pearl-Land Hospital, Kagoshima 891-1205, Japan.

{ddagger} Present address: GlaxoSmithKline Biologicals, B-1330 Rixensart, Belgium.

Journal of Virology, September 2003, p. 9716-9722, Vol. 77, No. 17
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.17.9716-9722.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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