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Journal of Virology, August 2003, p. 8555-8561, Vol. 77, No. 15
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.15.8555-8561.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Length of Epstein-Barr Virus Termini as a Determinant of Epithelial Cell Clonal Emergence

Cary A. Moody,1 Rona S. Scott,1 Tao Su,1 and John W. Sixbey1,2*

Department of Microbiology and Immunology,1 Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana2

Received 16 December 2002/ Accepted 3 May 2003

Reiterated terminal sequences of Epstein-Barr virus (EBV) DNA are numerically heterogeneous among infectious virions, providing a viral measure of clonality in infected cells. After in vitro infection, carcinoma cells bearing EBV episomes with fewer terminal repeats (TRs) proliferated faster. In single-cell clones, TR number varied inversely to the quantity of latent membrane protein 2A (LMP2A) transcripts whose unspliced precursors cross joined TRs. Thus, EBV clonality may reflect selection for a TR number that optimizes LMP2A-enhanced tumor progression, with infection occurring after epithelial cell transformation.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130. Phone: (318) 675-4272. Fax: (318) 675-5764. E-mail: jsixbe{at}lsuhsc.edu.

Journal of Virology, August 2003, p. 8555-8561, Vol. 77, No. 15
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.15.8555-8561.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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