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Journal of Virology, January 2003, p. 709-712, Vol. 77, No. 1
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.1.709-712.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Expression of CXCR4 on Feline Peripheral Blood Mononuclear Cells: Effect of Feline Immunodeficiency Virus Infection

Brian J. Willett,* Celia A. Cannon, and Margaret J. Hosie

Retrovirus Research Laboratory, Institute of Comparative Medicine, Department of Veterinary Pathology, University of Glasgow, Glasgow G61 1QH, United Kingdom

Received 30 May 2002/ Accepted 24 September 2002

CXCR4 expression on feline peripheral blood mononuclear cells (PBMC) was analyzed. While monocytes and B lymphocytes expressed CXCR4, no CXCR4 was detected on T lymphocytes, in stark contrast to the expression pattern on T lymphocytes from humans. In spite of the important role that CXCR4 plays in infection with feline immunodeficiency virus, expression on PBMC in vivo was unaffected by infection with either a primary or a cell culture-adapted virus strain.

* Corresponding author. Mailing address: Retrovirus Research Laboratory, Department of Veterinary Pathology, University of Glasgow, Bearsden Rd., Glasgow G61 1QH, United Kingdom. Phone: 44 141 330 3274. Fax: 44 141 330 5602. E-mail: b.willett{at}vet.gla.ac.uk.

Journal of Virology, January 2003, p. 709-712, Vol. 77, No. 1
0022-538X/03/$08.00+0     DOI: 10.1128/JVI.77.1.709-712.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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