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Journal of Virology, May 2002, p. 4621-4624, Vol. 76, No. 9
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.9.4621-4624.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Carboxy Terminus of Simian Virus 40 Large T Antigen Is Required To Disrupt the Yeast Cell Cycle

Sheara W. Fewell, Dena M. Markle, and Jeffrey L. Brodsky*

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260

Received 1 November 2001/ Accepted 25 January 2002

Wild-type and J domain mutant simian virus 40 large T antigens alter the cell cycle and bud morphology of Saccharomyces cerevisiae. In contrast, yeast cells expressing mutant T antigen lacking the carboxy-terminal 150 aa exhibit normal morphology, indicating that this region of T antigen is required for cell cycle disruption.

* Corresponding author. Mailing address: 267 Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260. Phone: (412) 624-4831. Fax: (412) 624-4759. E-mail: jbrodsky{at}pitt.edu.

Journal of Virology, May 2002, p. 4621-4624, Vol. 76, No. 9
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.9.4621-4624.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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