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Journal of Virology, April 2002, p. 3570-3574, Vol. 76, No. 7
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.7.3570-3574.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Inhibition of Hepatitis B Virus Replication by Interferon Requires Proteasome Activity{dagger}

Michael D. Robek, Stefan F. Wieland, and Francis V. Chisari*

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037

Received 28 September 2001/ Accepted 26 December 2001

Hepatitis B virus (HBV) replication is inhibited in a noncytopathic manner by alpha/beta interferon (IFN-{alpha}/ß) and IFN-{gamma}. We demonstrate here that inhibitors of cellular proteasome activity can block this antiviral effect. These results suggest that a critical component of the IFN-induced antiviral response may be the proteasome-dependent degradation of viral or cellular proteins that are required for HBV replication.

* Corresponding author. Mailing address: Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd. SBR-10, La Jolla, CA 92037. Phone: (858) 784-8228. Fax: (858) 784-2960. E-mail: fchisari{at}scripps.edu.

{dagger} Manuscript no. 14416-MEM from the Scripps Research Institute.

Journal of Virology, April 2002, p. 3570-3574, Vol. 76, No. 7
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.7.3570-3574.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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