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Journal of Virology, March 2002, p. 2563-2566, Vol. 76, No. 5
0022-538X/02/$04.00+0     DOI: 10.1128/jvi.76.5.2563-2566.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

B7 Costimulation Plays an Important Role in Protection from Herpes Simplex Virus Type 2-Mediated Pathology

*** Lydia G. Thebeau and Lynda A. Morrison*

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri 63104

Received 20 August 2001/ Accepted 28 November 2001

We have used mice lacking both B7-1 and B7-2 costimulation molecules (B7KO) to investigate the effects of B7 costimulation on herpes simplex virus type 2 (HSV-2) pathogenesis. B7KO mice infected intravaginally with virulent HSV-2 showed more severe genital and neurologic disease and higher mortality rates than their wild-type counterparts. These results suggest that B7 costimulation molecules play an important role in the development of primary immune responses protective against HSV-2.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis, MO 63104. Phone: (314) 577-8321. Fax: (314) 773-3403. E-mail: morrisla{at}slu.edu.

Journal of Virology, March 2002, p. 2563-2566, Vol. 76, No. 5
0022-538X/02/$04.00+0     DOI: 10.1128/jvi.76.5.2563-2566.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vagvala, S. P., Thebeau, L. G., Wilson, S. R., Morrison, L. A. (2009). Virus-Encoded B7-2 Costimulation Molecules Enhance the Protective Capacity of a Replication-Defective Herpes Simplex Virus Type 2 Vaccine in Immunocompetent Mice. J. Virol. 83: 953-960 [Abstract] [Full Text]  
  • Thebeau, L. G., Vagvala, S. P., Wong, Y. M., Morrison, L. A. (2007). B7 Costimulation Molecules Expressed from the Herpes Simplex Virus 2 Genome Rescue Immune Induction in B7-Deficient Mice. J. Virol. 81: 12200-12209 [Abstract] [Full Text]  
  • Zhang, P., Martin, M., Yang, Q.-B., Michalek, S. M., Katz, J. (2004). Role of B7 Costimulatory Molecules in Immune Responses and T-Helper Cell Differentiation in Response to Recombinant HagB from Porphyromonas gingivalis. Infect. Immun. 72: 637-644 [Abstract] [Full Text]  
  • Thebeau, L. G., Morrison, L. A. (2003). Mechanism of Reduced T-Cell Effector Functions and Class-Switched Antibody Responses to Herpes Simplex Virus Type 2 in the Absence of B7 Costimulation. J. Virol. 77: 2426-2435 [Abstract] [Full Text]  


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