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Journal of Virology, March 2002, p. 2548-2550, Vol. 76, No. 5
0022-538X/02/$04.00+0     DOI: 10.1128/jvi.76.5.2548-2550.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Abrogation of Ref1 Retrovirus Restriction in Human Cells

*** Greg Towers,* Mary Collins, and Yasuhiro Takeuchi

Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF, United Kingdom

Received 26 September 2001/ Accepted 26 November 2001

We have previously described postentry restriction of murine leukemia virus in mammals. Here we characterize the block in human cells. Restricted infection kinetics are multiple hit at high virus dose, and restriction is abrogated by preexposure to restricted virus. We hypothesize that restricted capsid can titrate out the restriction factor.

* Corresponding author. Mailing address: Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, 46 Cleveland St., London W1T 4JF, United Kingdom. Phone: 44-20-7679-9569. Fax: 44-20-7679-9555. E-mail: g.towers{at}ucl.ac.uk.

Journal of Virology, March 2002, p. 2548-2550, Vol. 76, No. 5
0022-538X/02/$04.00+0     DOI: 10.1128/jvi.76.5.2548-2550.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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