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Journal of Virology, February 2002, p. 1995-1998, Vol. 76, No. 4
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.4.1995-1998.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Herpes Simplex Virus ICP0 and ICP34.5 Counteract Distinct Interferon-Induced Barriers to Virus Replication

Karen L. Mossman{dagger} and James R. Smiley*

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada1

Received 23 July 2001/ Accepted 7 November 2001

Interferon inhibits virus replication through multiple mechanisms. Here we show that herpes simplex virus proteins ICP0 and ICP34.5 overcome interferon-induced barriers to viral transcription and translation, respectively. These cytokine-induced antiviral mechanisms are differentially expressed in established cell lines: U2OS cells do not mount the IFN-induced mechanism targeted by ICP0, and Vero cells may be defective for the mechanism targeted by ICP34.5.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, 1-41 Medical Sciences Bldg., University of Alberta, Edmonton, Alberta T6G 2H7, Canada. Phone: (780) 492-2308. Fax: (780) 492-7521. E-mail: jim.smiley{at}ualberta.ca.

{dagger} Present address: Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

Journal of Virology, February 2002, p. 1995-1998, Vol. 76, No. 4
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.4.1995-1998.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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