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Journal of Virology, December 2002, p. 13106-13110, Vol. 76, No. 24
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.24.13106-13110.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The CD154/CD40 Interaction Required for Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated by Upregulation of the CD80/CD86 Costimulatory Molecules

Kathy A. Green,1 W. James Cook,1 Arlene H. Sharpe,2 and William R. Green1*

Department of Microbiology and Immunology and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756,1 Brigham and Women's Hospital, Boston, Massachusetts 021152

Received 12 July 2002/ Accepted 11 September 2002

C57BL/6 (B6) mice infected with LP-BM5 retroviruses develop disease, including an immunodeficiency similar to AIDS. This disease, murine AIDS (MAIDS), is inhibited by in vivo anti-CD154 monoclonal antibody treatment. The similar levels of insusceptibility of CD40-/- and CD154-/- B6 mice indicate that CD154/CD40 molecular interactions are required for MAIDS. CD4+ T and B cells, respectively, provide the CD154 and CD40 expression needed for MAIDS induction. Here, the required CD154/CD40 interaction is shown to be independent of CD80 and CD86 expression: CD80/CD86-/- B6 mice develop MAIDS after LP-BM5 infection.

* Corresponding author. Mailing address: Dept. of Microbiology, Dartmouth Medical School, Borwell Bldg., 1 Medical Center Dr., Lebanon, NH 03756. Phone: (603) 650-8607. Fax: (603) 650-6223. E-mail: William.r.green{at}Dartmouth.edu.

Journal of Virology, December 2002, p. 13106-13110, Vol. 76, No. 24
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.24.13106-13110.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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