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Journal of Virology, November 2002, p. 11166-11171, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.11166-11171.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Influenza A Virus NS1 Protein Inhibits Activation of Jun N-Terminal Kinase and AP-1 Transcription Factors

Stephan Ludwig,1 Xiuyan Wang,2,3 Christina Ehrhardt,1 Hongyong Zheng,2 Nicola Donelan,2,3 Oliver Planz,4 Stephan Pleschka,5 Adolfo García-Sastre,2 Gudrun Heins,6 and Thorsten Wolff6*

Institut für Molekulare Medizin, Heinrich Heine-Universität, 40225 Düsseldorf,1 Institut für Immunologie, Bundesforschungsanstalt für Viruskrankheiten der Tiere, 72076 Tübingen,4 Institut für Virologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität, 35392 Giessen,5 Robert Koch-Institut, 13353 Berlin, Germany,6 Department of Microbiology,2 Microbiology Graduate School Training Program, Mount Sinai School of Medicine, New York, New York 100293

Received 4 March 2002/ Accepted 23 July 2002

The influenza A virus nonstructural NS1 protein is known to modulate host cell gene expression and to inhibit double-stranded RNA (dsRNA)-mediated antiviral responses. Here we identify NS1 as the first viral protein that antagonizes virus- and dsRNA-induced activation of the stress response-signaling pathway mediated through Jun N-terminal kinase.

* Corresponding author. Mailing address: Robert Koch-Institut, NG2, Nordufer 20, 13353 Berlin, Germany. Phone: 49-30-4547 2278. Fax: 49-30-4547 2328. E-mail: wolfft{at}RKI.de.

Journal of Virology, November 2002, p. 11166-11171, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.11166-11171.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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