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Journal of Virology, November 2002, p. 11139-11142, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.11139-11142.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Evidence for Early Infection of Nonneoplastic Natural Killer Cells by Epstein-Barr Virus

Pascal Trempat,1 Julie Tabiasco,1 Pascale Andre,2 Nathalie Faumont,1 Fabienne Meggetto,1 Georges Delsol,1 Randy D. Gascoyne,3 Jean-Jacques Fournie,1 Eric Vivier,4 and Pierre Brousset1*

Department of Pathology and Inserm U563, Centre de Physiopathologie de Toulouse, Purpan,1 Centre d'Immunologie de Marseille Luminy, Université de Marseille,4 Innate-Pharma, Marseille, France,2 Department of Pathology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada3

Received 20 March 2002/ Accepted 17 July 2002

We examined lymph nodes and tonsils from patients with infectious mononucleosis by combined detection of EBV-encoded RNA and a specific marker of natural killer (NK) cells, PEN5. A small number of Epstein-Barr virus (EBV) latently infected nonneoplastic NK cells were detected. Our data demonstrate that NK cells are natural targets of EBV and that infection of these cells is an early event observed during primary EBV infection.

* Corresponding author. Mailing address: Laboratoire d'Anatomie Pathologique, Place Baylac, CHU Purpan, 31059 Toulouse Cedex, France. Phone: 33 5 61 77 22 55. Fax: 33 5 61 49 90 36. E-mail: brousset.p{at}chu-toulouse.fr.

Journal of Virology, November 2002, p. 11139-11142, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.11139-11142.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Tabiasco, J., Vercellone, A., Meggetto, F., Hudrisier, D., Brousset, P., Fournie, J.-J. (2003). Acquisition of Viral Receptor by NK Cells Through Immunological Synapse. J. Immunol. 170: 5993-5998 [Abstract] [Full Text]  


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