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Journal of Virology, November 2002, p. 10921-10928, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.10921-10928.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Isolation of an Intertypic Poliovirus Capsid Recombinant from a Child with Vaccine-Associated Paralytic Poliomyelitis

Javier Martín,1* Elena Samoilovich,2 Glynis Dunn,1 Angie Lackenby,1 Esphir Feldman,2 Alan Heath,1 Ekaterina Svirchevskaya,2 Gill Cooper,1 Marina Yermalovich,2 and Philip D. Minor1

Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom,1 Department of Epidemiology and Immunoprophylaxis of Infectious Diseases, Research Institute for Epidemiology and Microbiology, Ministry of Health, Minsk, Republic of Belarus2

Received 5 April 2002/ Accepted 22 July 2002

The isolation of a capsid intertypic poliovirus recombinant from a child with vaccine-associated paralytic poliomyelitis is described. Virus 31043 had a Sabin-derived type 3-type 2-type 1 recombinant genome with a 5'-end crossover point within the capsid coding region. The result was a poliovirus chimera containing the entire coding sequence for antigenic site 3a derived from the Sabin type 2 strain. The recombinant virus showed altered antigenic properties but did not acquire type 2 antigenic characteristics. The significance of the presence in nature of such poliovirus chimeras and the consequences for the current efforts to detect potentially dangerous vaccine-derived poliovirus strains are discussed in the context of the global polio eradication initiative.

* Corresponding author. Mailing address: Division of Virology, National Institute for Biological Standards and Control, Blanche Ln., Potters Bar, Hertfordshire EN6 3QG, United Kingdom. Phone: (44) 1707 654753. Fax: (44) 1707 646730. E-mail: jmartin{at}nibsc.ac.uk.

Journal of Virology, November 2002, p. 10921-10928, Vol. 76, No. 21
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.21.10921-10928.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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