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Journal of Virology, October 2002, p. 10518-10523, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10518-10523.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Elevated Chemokine Responses Are Maintained in Lungs after Clearance of Viral Infection

Jason B. Weinberg,1,2 Mary L. Lutzke,1 Stacey Efstathiou,3 Steven L. Kunkel,4 and Rosemary Rochford1*

Department of Epidemiology,1 Division of Pediatric Infectious Diseases,2 Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109,4 Division of Virology and Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom3

Received 27 March 2002/ Accepted 3 July 2002

We observed two patterns of chemokine expression in the lungs of mice infected with murine gammaherpesvirus 68: peaks of chemokine expression correlated with or occurred after the peak of viral gene expression. Chemokine expression remained elevated through 29 days postinfection.

* Corresponding author. Mailing address: Department of Epidemiology, University of Michigan, 109 Observatory Rd., Ann Arbor, MI 48109-2029. Phone: (734) 764-5469. Fax: (734) 764-3192. E-mail: rochford{at}umich.edu.

Journal of Virology, October 2002, p. 10518-10523, Vol. 76, No. 20
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.20.10518-10523.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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