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Journal of Virology, January 2002, p. 923-927, Vol. 76, No. 2
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.2.923-927.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Alpha/Beta and Gamma Interferons Are Induced by Infection with Noncytopathic Bovine Viral Diarrhea Virus In Vivo

B. Charleston,* L. S. Brackenbury, B. V. Carr, M. D. Fray, J. C. Hope, C. J. Howard, and W. I. Morrison

Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom

Received 9 July 2001/ Accepted 11 October 2001

In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor ß (TGF-ß) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-ß.

* Corresponding author. Mailing address: Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. Phone: 44 (01635) 578411. Fax: 44 (01635) 577263. E-mail: bryan.charleston{at}bbsrc.ac.uk.

Journal of Virology, January 2002, p. 923-927, Vol. 76, No. 2
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.2.923-927.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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