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Journal of Virology, October 2002, p. 10060-10063, Vol. 76, No. 19
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.19.10060-10063.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Hepatitis B Surface Antigen Mutant That Lacks the Antigenic Loop Region Can Self-Assemble and Interact with the Large Hepatitis Delta Antigen

Brendan O'Malley and David Lazinski*

Department of Molecular Biology and Microbiology and the Raymond and Beverly Sackler Research Foundation Laboratory, Tufts University School of Medicine, Boston, Massachusetts 02111

Received 23 May 2002/ Accepted 3 July 2002

A novel hepatitis B virus surface antigen mutant harboring a deletion of most of the major antigenic loop region was competent for self-assembly and secretion. Although the mutant protein was competent for interaction with and incorporation of free large hepatitis delta antigen, it was partially defective in hepatitis delta virus RNP incorporation.

* Corresponding author. Mailing address: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111. Phone: (617) 636-3671. Fax: (617) 636-0337. E-mail: david.lazinski{at}tufts.edu.

Journal of Virology, October 2002, p. 10060-10063, Vol. 76, No. 19
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.19.10060-10063.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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