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Journal of Virology, September 2002, p. 9533-9536, Vol. 76, No. 18
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.18.9533-9536.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Core of Bluetongue Virus Binds Double-Stranded RNA

J. M. Diprose,1 J. M. Grimes,1 G. C. Sutton,1 J. N. Burroughs,2 A. Meyer,2 S. Maan,2 P. P. C. Mertens,2 and D. I. Stuart1,3*

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Headington, Oxford OX3 7BN,1 Pirbright Laboratory, Institute for Animal Health, Pirbright, Woking GU24 0NF,2 Oxford Centre for Molecular Sciences, Oxford University, Oxford OX1 3QT, United Kingdom3

Received 29 March 2002/ Accepted 12 June 2002

Double-stranded RNA (dsRNA) viruses conceal their genome from the host to avoid triggering unfavorable cellular responses. The crystal structure of the core of one such virus, bluetongue virus, reveals an outer surface festooned with dsRNA. This may represent a deliberate strategy to sequester dsRNA released from damaged particles to prevent host cell shutoff.

* Corresponding author. Mailing address: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Dr., Headington, Oxford OX3 7BN, United Kingdom. Phone: 44 1865 287567. Fax: 44 1865 287547. E-mail: dave{at}strubi.ox.ac.uk.

Journal of Virology, September 2002, p. 9533-9536, Vol. 76, No. 18
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.18.9533-9536.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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