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Journal of Virology, September 2002, p. 8963-8965, Vol. 76, No. 17
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.17.8963-8965.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Decelerating Decay of Latently Infected Cells during Prolonged Therapy for Human Immunodeficiency Virus Type 1 Infection

Viktor Müller,1* Javier Flavio Vigueras-Gómez,2 and Sebastian Bonhoeffer1

Ecology and Evolution, ETH Zürich, 8092 Zürich, Switzerland,1 INRIA-Lorraine, 54600 Villers-les-Nancy, France2

Received 12 February 2002/ Accepted 20 May 2002

Antiviral therapy induces a rapid drop in human immunodeficiency virus type 1 viremia, but the decline of virus levels decelerates over time. Mathematical modeling demonstrates that the source of residual virus production might be a single compartment of latently infected cells with an extended distribution of activation rates.

* Corresponding author. Mailing address: Ecology and Evolution, ETH Zürich, Clausiusstr. 25, ETH Zentrum NW, 8092 Zürich, Switzerland. Phone: (41) 1 6327105. Fax: (41) 1 6321271. E-mail: mueller{at}eco.umnw.ethz.ch.

Journal of Virology, September 2002, p. 8963-8965, Vol. 76, No. 17
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.17.8963-8965.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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