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Journal of Virology, August 2002, p. 8455-8459, Vol. 76, No. 16
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.16.8455-8459.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity and Replication Independently of Viral Coreceptor Tropism

Armin Papkalla,1 Jan Münch,2 Claas Otto,2 and Frank Kirchhoff2*

Institute for Clinical and Molecular Virology, University of Erlangen-Nürnberg, 91054 Erlangen,1 Department of Virology, University of Ulm, 89081 Ulm, Germany2

Received 21 February 2002/ Accepted 17 May 2002

We investigated the infectivities and replicative capacities of a large panel of variants of the molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate that Nef enhances virion infectivity and HIV-1 replication independently of the viral coreceptor tropism.

* Corresponding author. Mailing address: Department of Virology, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Phone: 49-731-50023344. Fax: 49-731-50023389. E-mail: frank.kirchhoff{at}medizin.uni-ulm.de.

Journal of Virology, August 2002, p. 8455-8459, Vol. 76, No. 16
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.16.8455-8459.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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