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Journal of Virology, August 2002, p. 7910-7912, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7910-7912.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Successful Boosting of a DNA Measles Immunization with an Oral Plant-Derived Measles Virus Vaccine

Diane E. Webster,1 Michelle L. Cooney,2 Zhongjun Huang,1 Damien R. Drew,3 Ian A. Ramshaw,4 Ian B. Dry,5 Richard A. Strugnell,3 Jenny L. Martin,2 and Steve L. Wesselingh1,2*

Department of Medicine,1 Department of Microbiology, Monash University Medical School, Alfred Hospital, Prahran, Victoria 3181,2 Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3052,,3 John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601,4 Horticulture Unit, CSIRO Plant Industry, Glen Osmond, South Australia 5064, Australia5

Received 17 December 2001/ Accepted 26 April 2002

Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.

* Corresponding author. Mailing address: Department of Medicine, Monash University Medical School, Alfred Hospital, Commercial Rd., Prahran, Victoria 3181, Australia. Phone: 61 3 9276 3087. Fax: 66 3 9276 2431. E-mail: s.wesselingh{at}alfred.org.au.

Journal of Virology, August 2002, p. 7910-7912, Vol. 76, No. 15
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.15.7910-7912.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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