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Journal of Virology, July 2002, p. 6832-6835, Vol. 76, No. 13
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.13.6832-6835.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Human Cytomegalovirus US8 Glycoprotein Binds to Major Histocompatibility Complex Class I Products

Rebecca S. Tirabassi and Hidde L. Ploegh*

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Received 22 January 2002/ Accepted 8 April 2002

Human cytomegalovirus US8 is a type I membrane protein that partially colocalizes with cellular endosomal and lysosomal proteins. Although US8 does not have discernible effects on the processing and cell surface distribution of major histocompatibility complex (MHC) class I products, we have demonstrated that US8 binds to MHC class I heavy chains in the endoplasmic reticulum.

* Corresponding author. Mailing address: Department of Pathology, Harvard Medical School, 200 Longwood Ave. D2-137, Boston, MA 02115. Phone: (617) 432-4776. Fax: (617) 432-4775. E-mail: ploegh{at}hms.harvard.edu.

Journal of Virology, July 2002, p. 6832-6835, Vol. 76, No. 13
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.13.6832-6835.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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