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Journal of Virology, June 2002, p. 5829-5834, Vol. 76, No. 11
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.11.5829-5834.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Diarrhea-Inducing Activity of Avian Rotavirus NSP4 Glycoproteins, Which Differ Greatly from Mammalian Rotavirus NSP4 Glycoproteins in Deduced Amino Acid Sequence, in Suckling Mice

Yoshio Mori, Mohammed Ali Borgan, Naoto Ito, Makoto Sugiyama, and Nobuyuki Minamoto*

Department of Veterinary Public Health, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan

Received 10 September 2001/ Accepted 25 February 2002

Avian rotavirus NSP4 glycoproteins expressed in Escherichia coli acted as enterotoxins in suckling mice, as did mammalian rotavirus NSP4 glycoproteins, despite great differences in the amino acid sequences. The enterotoxin domain of PO-13 NSP4 exists in amino acid residues 109 to 135, a region similar to that reported in SA11 NSP4.

* Corresponding author. Mailing address: Department of Veterinary Public Health, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. Phone and fax: 8158-293-2948. E-mail: minamoto{at}cc.gifu-u.ac.jp.

Journal of Virology, June 2002, p. 5829-5834, Vol. 76, No. 11
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.11.5829-5834.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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