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Journal of Virology, May 2002, p. 5274-5277, Vol. 76, No. 10
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.10.5274-5277.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Activation of NF-{kappa}B by R5 and X4 Human Immunodeficiency Virus Type 1 Induces Macrophage Inflammatory Protein 1{alpha} and Tumor Necrosis Factor Alpha in Macrophages

Wonkyu Choe, David J. Volsky, and Mary Jane Potash*

Division of Molecular Virology, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, New York 10019

Received 5 November 2001/ Accepted 15 February 2002

NF-{kappa}B is a transcriptional activator that often regulates inflammatory responses. We demonstrate that human immunodeficiency virus type 1 activates nuclear localization of NF-{kappa}B in macrophages in a manner dependent upon virus strain but independent of virus replication. Through the use of an inhibitor, NF-{kappa}B activation was found to be responsible for the cytokine and chemokine induction that we recently reported.

* Corresponding author. Mailing address: Molecular Virology Division, 432 West 58th St., New York, NY 10019. Phone: (212) 582-4451. Fax: (212) 582-5027. E-mail: mjp6{at}columbia.edu.

Journal of Virology, May 2002, p. 5274-5277, Vol. 76, No. 10
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.10.5274-5277.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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