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Journal of Virology, May 2001, p. 4399-4401, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4399-4401.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Measles Viruses on Throat Swabs from Measles Patients Use Signaling Lymphocytic Activation Molecule (CDw150) but Not CD46 as a Cellular Receptor

Nobuyuki Ono,1 Hironobu Tatsuo,1 Yasufumi Hidaka,2 Tomonobu Aoki,3 Hiroko Minagawa,1 and Yusuke Yanagi1,*

Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582,1 Department of Pediatrics, Kitakyushu Municipal Medical Center, Kitakyushu 802-0077,2 and Fukuoka City Children's Hospital and Medical Center for Infectious Disease, Fukuoka 810-0063,3 Japan

Received 7 December 2000/Accepted 29 January 2001

Both CD46 and signaling lymphocytic activation molecule (SLAM) have been shown to act as cellular receptors for measles virus (MV). The viruses on throat swabs from nine patients with measles in Japan were titrated on Vero cells stably expressing human SLAM. Samples from all but two patients produced numerous plaques on SLAM-expressing Vero cells, whereas none produced any plaques on Vero cells endogenously expressing CD46. The Edmonston strain of MV, which can use either CD46 or SLAM as a receptor, produced comparable titers on these two types of cells. The results strongly suggest that the viruses in the bodies of measles patients use SLAM but probably not CD46 as a cellular receptor.

* Corresponding author. Mailing address: Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan. Phone: 81-92-642-6135. Fax: 81-92-642-6140. E-mail: yyanagi{at}virology.med.kyushu-u.ac.jp.

Journal of Virology, May 2001, p. 4399-4401, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4399-4401.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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