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Journal of Virology, May 2001, p. 4165-4175, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4165-4175.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Vaccine-Elicited V3 Loop-Specific Antibodies in Rhesus Monkeys and Control of a Simian-Human Immunodeficiency Virus Expressing a Primary Patient Human Immunodeficiency Virus Type 1 Isolate Envelope

Norman L. Letvin,1,* Suzanne Robinson,1 Daniela Rohne,1 Michael K. Axthelm,2 John W. Fanton,2 Miroslawa Bilska,3 Thomas J. Palker,3,dagger Hua-Xin Liao,3 Barton F. Haynes,3 and David C. Montefiori3

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 022151; Oregon Regional Primate Research Center, Beaverton, Oregon 970062; and Duke University Medical Center, Durham, North Carolina 277103

Received 13 July 2000/Accepted 27 January 2001

Vaccine-elicited antibodies specific for the third hypervariable domain of the surface gp120 of human immunodeficiency virus type 1 (HIV-1) (V3 loop) were assessed for their contribution to protection against infection in the simian-human immunodeficiency virus (SHIV)/rhesus monkey model. Peptide vaccine-elicited anti-V3 loop antibody responses were examined for their ability to contain replication of SHIV-89.6, a nonpathogenic SHIV expressing a primary patient isolate HIV-1 envelope, as well as SHIV-89.6P, a pathogenic variant of that virus. Low-titer neutralizing antibodies to SHIV-89.6 that provided partial protection against viremia following SHIV-89.6 infection were generated. A similarly low-titer neutralizing antibody response to SHIV-89.6P that did not contain viremia after infection with SHIV-89.6P was generated, but a trend toward protection against CD4+ T-lymphocyte loss was seen in these infected monkeys. These observations suggest that the V3 loop on some primary patient HIV-1 isolates may be a partially effective target for neutralizing antibodies induced by peptide immunogens.

* Corresponding author. Mailing address: Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P.O. Box 15732, Boston, MA 02215. Phone: (617) 667-2766. Fax: (617) 667-8210. E-mail: nletvin{at}caregroup.harvard.edu.

dagger Present address: Merck Research Laboratories, West Point, PA 19486.

Journal of Virology, May 2001, p. 4165-4175, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4165-4175.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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