This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by An, D. S.
Right arrow Articles by Chen, I. S. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by An, D. S.
Right arrow Articles by Chen, I. S. Y.

 Previous Article  |  Next Article 

Journal of Virology, April 2001, p. 3488-3489, Vol. 75, No. 7
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.7.3488-3489.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Envelope Gene of the Human Endogenous Retrovirus HERV-W Encodes a Functional Retrovirus Envelope

Dong Sung An, Yi-ming Xie, and Irvin S. Y. Chen*

Department of Microbiology, Immunology, Molecular Genetics, and Medicine, UCLA AIDS Institute, University of California---Los Angeles, Los Angeles, California 90095

Received 27 October 2000/Accepted 12 January 2001

A member of the human endogenous retrovirus (HERV) family termed HERV-W encodes a highly fusogenic membrane glycoprotein that appears to be expressed specifically in the placenta. It is unclear whether the glycoproteins of the HERVs can serve as functional retrovirus envelope proteins to confer infectivity on retrovirus particles. We found that the HERV-W envelope glycoprotein can form pseudotypes with human immunodeficiency virus type 1 virions and confers tropism for CD4-negative cells. Thus, the HERV-W env gene represents the first HERV env gene demonstrated to encode the functional properties of a retrovirus envelope glycoprotein.

* Corresponding author. Mailing address: University of California, Los Angeles, Department of Microbiology, Immunology, Molecular Genetics and Medicine, 10833 Le Conte Ave., 11-934 Factor Bldg., Los Angeles, CA 90095. Phone: (310) 825-4793. Fax: (310) 794-7682. E-mail: rtaweesu{at}ucla.edu.

Journal of Virology, April 2001, p. 3488-3489, Vol. 75, No. 7
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.7.3488-3489.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Woodward, C. L., Prakobwanakit, S., Mosessian, S., Chow, S. A. (2009). Integrase Interacts with Nucleoporin NUP153 To Mediate the Nuclear Import of Human Immunodeficiency Virus Type 1. J. Virol. 83: 6522-6533 [Abstract] [Full Text]  
  • Antony, J. M., Ellestad, K. K., Hammond, R., Imaizumi, K., Mallet, F., Warren, K. G., Power, C. (2007). The Human Endogenous Retrovirus Envelope Glycoprotein, Syncytin-1, Regulates Neuroinflammation and Its Receptor Expression in Multiple Sclerosis: A Role for Endoplasmic Reticulum Chaperones in Astrocytes. J. Immunol. 179: 1210-1224 [Abstract] [Full Text]  
  • Dewannieux, M., Blaise, S., Heidmann, T. (2005). Identification of a Functional Envelope Protein from the HERV-K Family of Human Endogenous Retroviruses. J. Virol. 79: 15573-15577 [Abstract] [Full Text]  
  • Cheynet, V., Ruggieri, A., Oriol, G., Blond, J.-L., Boson, B., Vachot, L., Verrier, B., Cosset, F.-L., Mallet, F. (2005). Synthesis, Assembly, and Processing of the Env ERVWE1/Syncytin Human Endogenous Retroviral Envelope. J. Virol. 79: 5585-5593 [Abstract] [Full Text]  
  • Potgens, A.J.G., Drewlo, S., Kokozidou, M., Kaufmann, P. (2004). Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action. Hum Reprod Update 10: 487-496 [Abstract] [Full Text]  
  • Bannert, N., Kurth, R. (2004). Retroelements and the human genome: New perspectives on an old relation. Proc. Natl. Acad. Sci. USA 101: 14572-14579 [Abstract] [Full Text]  
  • Bonnaud, B., Bouton, O., Oriol, G., Cheynet, V., Duret, L., Mallet, F. (2004). Evidence of Selection on the Domesticated ERVWE1 env Retroviral Element Involved in Placentation. Mol Biol Evol 21: 1895-1901 [Abstract] [Full Text]  
  • Blaise, S., Ruggieri, A., Dewannieux, M., Cosset, F.-L., Heidmann, T. (2004). Identification of an Envelope Protein from the FRD Family of Human Endogenous Retroviruses (HERV-FRD) Conferring Infectivity and Functional Conservation among Simians. J. Virol. 78: 1050-1054 [Abstract] [Full Text]  
  • Blaise, S., de Parseval, N., Benit, L., Heidmann, T. (2003). Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc. Natl. Acad. Sci. USA 100: 13013-13018 [Abstract] [Full Text]  
  • Marin, M., Lavillette, D., Kelly, S. M., Kabat, D. (2003). N-Linked Glycosylation and Sequence Changes in a Critical Negative Control Region of the ASCT1 and ASCT2 Neutral Amino Acid Transporters Determine Their Retroviral Receptor Functions. J. Virol. 77: 2936-2945 [Abstract] [Full Text]  
  • Lavillette, D., Marin, M., Ruggieri, A., Mallet, F., Cosset, F.-L., Kabat, D. (2002). The Envelope Glycoprotein of Human Endogenous Retrovirus Type W Uses a Divergent Family of Amino Acid Transporters/Cell Surface Receptors. J. Virol. 76: 6442-6452 [Abstract] [Full Text]  
  • Benit, L., Dessen, P., Heidmann, T. (2001). Identification, Phylogeny, and Evolution of Retroviral Elements Based on Their Envelope Genes. J. Virol. 75: 11709-11719 [Abstract] [Full Text]  
  • Overbaugh, J., Miller, A. D., Eiden, M. V. (2001). Receptors and Entry Cofactors for Retroviruses Include Single and Multiple Transmembrane-Spanning Proteins as well as Newly Described Glycophosphatidylinositol-Anchored and Secreted Proteins. Microbiol. Mol. Biol. Rev. 65: 371-389 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»